2019-nCoV hot topics and cure

FEATURES:

2019-nCoV according to Chinese and Indian studies suggest is human created , having as special feature a high mutation rate on spike proteins in charge of attaching to the healthy host cell. That's why this virus has higher transmission rates than SARS and flu. In fact this virus looks more like HIV and Ebola than SARS or flu, since is a enveloped (packaged) virus that can enter the cell through the membrane fusion.

The hot topic discovered on 2019-nCoV is that has HIV insertions on its spike proteins,proofing that is manmade to harm people. There are 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Amino acid residues in all them have identity to those in the HIV1 gp120 or HIV-1 Gag. Despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site suggesting is unlikely to be fortuitous in nature.

2019-nCoV secreted viral particles to the host cell surface protein GP120 (responsible for binding to the receptor) is the spike protein S1 (responsible for binding to the receptor) and for host cell GP41 (responsible for membrane fusion)  is the S2 (responsible for membrane fusion). Fusion mechanism is similar to HIV and Ebola,by targeting an enzyme called furin, which works as a protein activator in the human body.

ORIGIN:

The unique level 4 (high risk virus handling) Microbiology Laboratory in China is Wuhan's Institute of Virology, that hints virus could have been leaked accidentally from there, knowing that some cases they sold infected animals to the nearby markets to make some extra cash, where the outbreak started.To add more light on the origin of the spread, one article published July 2019 before the outbreak points out a espionage case between Canada and China, in which a Chinese researcher working in a Canadian microbiology institute was  removed credentials from a  level-4 lab. It could be that in the afterwards of the Huawei CFO detention in Canada , China tried to stole pharma assets from that Candian laboratory that ended up in Wuhan with an insufficient caring.

So the rationale design for this biological weapon whoever created it is: let's get an isolated flu, let's attach to it properties of HIV (large dormant period) in order to increase the spread capabilities, let's alter genome to increase mutability rate. Then you get 2019-nCoV. While SARS killed around 10% of patients, 2019-nCoV kills around 2%. The difference is that 2019-nCoV is significantly more contagious so you can achieve more casualities. Covid-19’s ability to bind to cells is 100 to 1,000 times stronger than SARS.

HOW CAN WE FIGHT IT?

Virus are a billionaire lucrative business for pharma industry, that own pensions plans, lobby the supranational organizations that rule the countries (OMS, EU) and influence the most of the national budget, since it is dedicated to healthcare. They will research, provide you a vaccine by amending the original virus, force states to purchase it, and fix the problem for 1 year until next mutation. So do not expect long term or definitive solutions from the mainstream and official sources. Rather think by yourself:

A) ON YOUR SIDE:

Enveloped virus  such 2019-nCoV are the easier to kill, they die at 38 C. How can be achieved?

a) naturally fight via fever

b) artificially: sport, infrared sauna, warm weather. Always to be applied in short periods during day, since long term heat exposure dampens immune system

c) sleeping, where natural immune system kills pathogens

Was it easy? Let me show you a personal sample. Last 2 years i have had an average of only 2-3 days fever per year on winter, at upper respiratory system. I do regularly sport and sauna. Last time i took antibiotics was 3 years ago. However my partner is having almost 1 month per year, my relatives (mother, sister) 2-3 weeks years, including lower lung affections. They do not have these habits at all and rely continuously on antibiotics. The kind of sport i do is weight workout, 1 h 30 min each 48 hours. Sauna 15 min at the end. I run 30' per week for 5 km. I found out that intensive cardiovascular training such marathons is worst and immunosupressant. Some colleagues of mine running 40 km week get longer colds (2 weeks).

b) helps to achieve better c). People stressed , with panic to the virus, being tagged as 2019-nCoV carriers, confined to hospitals (a big source of other diseases) do not sleep properly. Lack of sleeping is immunosupressant and ends killing you. What should you do if feeling mild symptoms?  Confine yourself at home having no one closer than 1 meter. Try to do b) in an isolated environment and do not stop at all you habits. Sleeping profoundly without durgs is crucial. Logically if serious lung complications you have to go to the doctor.

B) RESEARCHERS:

Human body contains a full human virome specially on the intestine. So we live with thousands of virus all our life. Blood analysis on healthy people finds Herpesviridae, Influenzavirus, RNA virus such HIV, coronavirus, etc with no problems. Virus is a parasite that needs a live host to spread it. There is no interest at all in killing it. In fact we are macroscopic virus. The problem is the viral load. When the higher, then is associated the disease symptoms. Viral load is caused by bad behaviour of own immune system. 

So why people (elderly) dies from 2019-nCoV ?  They do not die because virus, they die due to the exaggerated own immune response that stiffens, floods and damages the lung cells, provoking respiratory insufficiency. They die from friendly fire attack on the form of holes and scars on lung tissues created by the immune system’s hyperactive response.

Therefore why pharma industry insists in killing/deactivating the virus with antivirals/vaccines instead controlling properly the own immune system reaction? Because first can be sold on the market in form of a drug, that provide seasonal solution (no matter side effects that can be diluted in unprofessional testings such Monsanto-Roundup case). 

So the right and fast pathway is to learn how to control cytokines level in blood, since they are proteins used by the immune system as alarm beacons. So affected carriers being following up periodically by specialized doctors at home and applying agents to reduce cytokin storm via antinflammatories can be the solution. Although excessive inflammatory responses are harmful to lung tissue, inflammatory cells are essential for repair and regeneration because these cells are important cleaners that remove harmful pathogens as well as debris derived from apoptotic and necrotic cells. Inflammatory cells, especially phagocytic monocytes including alveolar macrophages, produce cytokines and growth factors to resolve inflammation and promote tissue repair and regeneration by inducing tissue-resident stem cells.

So the key point i would recommend to Pharma industry and researchers is to invest and focus on having formulas to keep a balanced level of inflammatory response, instead of deep diving on expensive spike DNA rendering and vaccines manufacturing, that do not solve the problem at long term, has side effects and could end again in leakage of harmful virus from laboratories.